Showing posts with label cats. Show all posts
Showing posts with label cats. Show all posts

Monday, December 9, 2024

Cat Domestication Study Using Mummies

  

Cat Domestication Study Using Mummies


    Dr. Claudio Ottoni and other researchers are using ancient DNA to study cat domestication. The aim of their study is to understand the biological and environmental factors that shaped the evolution of domestic cats and trace how cats spread around the world. Cats domestication is unique because while cats are adapted to humans, they still retained most of their wild instincts. Genetic analysis suggests domestic cats came from North Africa and entered Europe around 2,500 years ago. This is much later than other domesticated animals making cats a unique case.

    The researchers have analyzed over 1,300 fossilized cats including some cat mummies from archaeological sites in Europe, Africa, and Southwest Asia with the cats dating back as far as 10,000 BC. The researchers specifically wanted to look at Egyptian cat mummies because of cats long history in Egypt but mummification damages DNA. However, using advanced genetic sequencing they are now able to recover more of the DNA.

https://phys.org/news/2024-11-journey-egyptian-cat-mummies-modern.html


https://projects.research-and-innovation.ec.europa.eu/en/horizon-magazine/tracing-journey-egyptian-cat-mummies-modern-house-pets



Monday, April 8, 2024

Bengal Cat Coats Are Less Wild Than They Look, Genetic Study Finds

Sarah C.P. Williams, from Stanford Medicine, writes that Bengal cats have marbled and spotted coats that make them look like smaller versions of jungle cats. It was assumed that the coats they have come from genes of Asian leopard cats that were bred with house cats, but now researchers are finding new evidence for another reason. They have discovered that their coat can be traced back to domestic cat genes that were aggressively selected for after cats were bred with wild cats. The appearance of the Bengal cat has always been present in domestic cat and through breeding they were able to bring the genes out. 

Cats are a good subject to use when studying how genetic variation leads to variation in appearance.  Asian leopard cat species Prionailurus bengalensis was crossed with domestic cats to create a new breed. Over many generations, cats with desired traits were selectively bred. Bengals were an interesting subject to study because they a recent genetic origin and unique appearance. This information is incredibly valuable to breeders because they will be able to “fine-tune” the way they breed animals to create new colors and patterns. Breeders are contributing their cats’ DNA for the study and want to be part of the data analysis as they are interested in learning more about their cat. Artificial selection is powerful, and research are just starting to realize this as they have discovered that Bengal cat coats could have possibly been selected without the help of the Asian leopard cat. 

As someone with an interest and a love for cats reading this article was intriguing. I never would have thought that the reason for the Bengals coats wasn’t because they were being bred from Asian leopard cats. It was interesting to learn that the coat colors came from the domestic cat and the genes were coaxed from specific breeding. 


Controversy of the Tiger Cats

    Going back to 2013, there were two new Latin American tiger cat species recognized. These two species were "the southern tiger cat (Leopardus guttulus) and northern tiger cat (Leopardus tigrinus)" of which they were both deemed vulnerable by the IUCN Red List. Recently in 2024, a paper published by Scientific Reports was released that described a third tiger cat species called Leopardus pardinoides

    The biggest debate after the release of this paper lies in understanding the distribution and the vulnerability of each tiger cat species to make sure they are all properly protected and documented. With many protected species, the main thing to do to help them is protect their habitat and prevent habitat loss. With the discovery of a new tiger cat, finding what they need is crucial for their protection. 

    Finding where they are located on the map is also something important to be able to document and protect the tiger cats as a whole. Of course with the new species, the original map has to be completely revised. This also means that there is likely less of each species than they originally thought which shows as a population drop. It was stated that "based on historical distribution, the authors estimated an alarming 55.9% range reduction for L. tigrinus, 50.4% for L. pardinoides, and 68.2% for L. gutullus". 

    Another concern is the spread of diseases by stray dogs in the area to these three tiger cat species. Since these tiger cats are considered endangered species, it's even more concerning for officials. With another controversy over another debated tiger cat species Leopardus narinensis, the water of the debate continues to stay muddy.

    Overall, coming to a conclusion of whether they are a completely newly discovered species is extremely important for their preservation. This leads to more control over land preservation to prevent them from going extinct as well as the management of local stray dogs and possible diseases that could affect the tiger cat population. Getting more of an idea of the areas they inhabit and their population will make it much easier to decide how critical their endangered status is which therefore should determine the amount of intervention required to preserve them.


Composite image details the differences in appearance between the three tiger cats. Each is slightly different in body size and shape, and with differing spot patterns. Curiously, the newly described L. pardinoides has only one pair of teats, while the others have two. A) represents the savanna tiger cat, L. tigrinus; B) represents the newly proposed clouded tiger cat, L. pardinoides; and c) the Atlantic Forest tiger cat, L. guttulus. A likely revision of these species’ threat status could see all three classified as endangered. Image courtesy of de Oliveira et al., 2024.Article title - A tiger cat gains new species designation, but conservation challenges remain
"Composite image details the differences in appearance between the three tiger cats. Each is slightly different in body size and shape and with differing spot patterns. Curiously, the newly describes L. pardinoides has only one pair of teats while the others have two" (Oliveira et al., 2024).
A is the savanna tiger cat (L. tigrinus), B is the possible clouded tiger cat (L. pardinoides), and C is the Atlantic Forest tiger cat (L. guttulus). 


Resources:

(News Article) https://news.mongabay.com/2024/04/a-tiger-cat-gains-new-species-designation-but-conservation-challenges-remain/

(Scientific Article) https://www.nature.com/articles/s41598-024-52379-8

(Alternative Link) https://wildcatconservation.org/wild-cats/south-america/northern-tiger-cat/

Tuesday, March 26, 2024

Are Bengal Cats Less Exotic than They Seem?

Source https://med.stanford.edu/news/all-news/2024/03/bengal-cats.html

Reference https://www.purina.co.uk/find-a-pet/cat-breeds/bengal


Sarah C.P. Williams’ article posted on Stanford Medicine stated that researchers at Stanford Medicine studied the origins of Bengal cat’s coats and determined that it most likely stemmed from domesticated cats. These cats were assumed to be bred from the genes of an Asian leopard and a house cat. Many people want bengal cats because of their wild-like leopard appearance but domesticated personality. However, it has been reported that the appearance of Bengal cats have always been around in domesticated cats. 

Researcher Gregory Brash and his colleagues sequenced 947 Bengal cat genomes and found that there were no parts of the Asian leopard cat genomes that would have been assumed to be found in all Bengals. Instead, the results determined that the appearance of Bengals was a result of genetic variations that were already present in domestic cats. In the end, it was decided that the ideal Bengal Cat coat could have been achieved with the simple domestic cat genome. 

This research is very interesting. Not only does it determine that Bengal cats are not as exotic as originally thought, but it also highlights the fact that many people are paying, on average $1,500 – $3,000 on a cat that is not actually what it seems. I am curious to see if the prices of Bengal cats decrease as a result of this study. 




Tuesday, December 5, 2023

Why Do Cats Live Longer Than Dogs?

 We all wish our furbabies could live forever, but have you ever thought about why cats live longer than dogs? Both are domesticated animals, but the gap between the lifespans is interesting. Dr Steve Austad, a lion trainer turned biologist, said: "There is an evolutionary theory of aging... that suggests that things live longer in safe conditions. Think of cats' solitary ways. Unlike dogs, which are pack animals, they live at low density and that tends to prevent them from catching infectious diseases." 


Cats have a faster metabolic rate than dogs, due to evolution and their natural predators. These characteristics are due to their genetic diversity, cats are more resilient to disease and environmental issues, unlike dogs. Another genetic issue with dogs is many of them are inbred which leads to more genetic disorders. A lower risk of genetic disorders equals a longer lifespan. 

In the past years, veterinarian advancements have given cats a longer lifespan due to the new treatments, and ranges of conditions they can treat. They have improved on many surgical techniques, and therapy treatments as well. Also as a pet owner, it is important that you know your pet and make sure there is a good relationship between you and their veterinarian so you can help better your animal's life and live a longer healthier life.


Links:


Cats vs. Dogs


Cats Lifespan



Sunday, August 6, 2023

Feline Genetics Help To Find First Ever Domestication Of Cats

Around 10,000 years ago, humans in the Middle East's Fertile Crescent transitioned from hunting and gathering to farming. They formed partnerships with cats, which aided in pest control. A University of Missouri study led by feline geneticist Leslie A. Lyons traced the domestication of cats to this period. Through DNA analysis of cats from the Fertile Crescent, Europe, Asia, and Africa, using markers like microsatellites and single nucleotide polymorphisms, the study revealed that the Fertile Crescent was likely the first site of cat domestication. Cats accompanied humans during their global travels, resulting in diverse cat populations. These semi-domesticated cats maintained much of their natural behavior. This research supports Lyons' broader aim of using cats for biomedical research, with genetic tools aiding disease studies. The study highlights the genetic similarities between cats and humans and the potential for using cats to study diseases shared by both species.


Tuesday, December 6, 2022

Feline genetics help pinpoint first-ever domestication of cats

 A study at the university of Missouri has determined how long ago cats were domesticated. Leslie Lyons, a feline geneticist, has studied about 200 gene markers in cats from around the world to help pinpoint this domestication. One of these gene markers was microsatellites, which are quickly mutating. 

For a lot of other domesticated species, it seems that they have had multiple domestication events over the years, while cats seem to have been domesticated once, about 10,000 years ago, as humans began to migrate. When humans began to migrate, it seems they felt the need to bring cats with them, which I can't blame them for. 

Cats are also referred to as "semi domesticated" because although cats do well in human care, if they were let outside on their own, they could fend for themselves and hunt just fine. 

https://www.sciencedaily.com/releases/2022/12/221205121616.htm



Wednesday, April 27, 2022

Creating a Hypoallergenic Cat

   An article from Science Tech Daily talks about how researchers from InBio are working on developing a cat that is hypoallergenic and safe for those who suffer with allergies to cats. People who are allergic to cats are allergic to a protein called Fel d 1 that is shed by all cats. Researchers looked at the Fel d 1 gene in 50 domestic cats in order to find a coding region that can be used in CRISPR editing, and when compared to a handful of exotic cat samples it was determined that with the amount of variation seen suggests that Fel d 1 is nonessential for cats. Researchers have used CRISPR- Cas9 to disturb the Fel d 1 with relative sucess, and they are hoping that they will be able to use gene deletion technology to remove the Fel d 1 from some cats making them safe for cat allergy sufferers. 

    I think this is an amazing feat of science and technology, and as someone who knows many people who suffer from cat allergies but still love cats, I think this will help animal people all over the world. Like dogs, cats can offer many therapeutic benefits, but because there is no hypoallergenic breed of cat people who suffer from allergies to cats cannot appreciate the benefits of owning at cat. I'm hoping in the near future that cat allergy sufferers will soon be able to interact with the first hypoallergenic cats. 

Other links:

CRISPR Journal

Sunday, April 24, 2022


     An article written by Elizabeth Gamillo for the Smithsonian Magazine discusses CRISPER gene editing technology and cats. Researchers are using CRISER to engineer hypoallergenic felines. They way this is possible is by blocking genes responsible for a major cat allergen. 

    InBio, a United States biotech company is removing sections of DNA in cats at specific locations in the genome. After analyzing DNA in 50 domestic cats researchers identified regions along the two genes that the team could cut and edit with CRISPR. This is the first step in being able to breed the resulting hypoallergenic cats to produce offspring that are not genetically modified.

    Removing the allergen causing gene is anticipated to not cause any health risks to the cat. And the protein is believed to be not essential for survival. There are ways to reduce the amount of the allergen causing gene without the use of CRISPER, but not totally remove it. 

Thursday, December 9, 2021

The Genes that are Behind Cat's Spots & Stripes

Cats have spots and stripes all over their body on their fur. Do you ever wonder how it gets there? Researchers have found a specific gene that all domestic and wild big cat species develop spots and stripes. The gene that was responsible for this is the DKK4 gene which is found to be active in thick skin as opposed to thinner skin. It was found to be known for fur with a blur of colors which is a mutation from the DKK4 gene. The all-white and all-black cats have patterns underneath their fur. However, the pigment lacks in white cats as opposed to other solid-colored cats because the pattern is overridden by instructions to produce one color. The WNTs protein is also essential because it works closely with DKK4 to form a prepattern that is 2 to 3 millimeters long. The color differences that control the coat color variation are also similar to the gene that's responsible in cheetahs and thicker, more prominent fur patterns. Other than the WNTs protein and DDK gene, there are more unknown genes that are behind why some cats have spots and why some cats have stripes. 

Thursday, November 11, 2021

Colorful Cats


    Researchers have long studied the coat color patterns of an array of animals. One of these many animals is the cat. Researchers like Dr. Gregory Brash decided to take it upon themselves to study the coat patterns and colors of domestic cats. They found that there was development in fetal cats for coat color and pattern long before there would ever be hair. They called this "prepattern" a pattern set in the skin that would later correlate to stripes or spots. The stage this happens in is referred to as "embellishment," the body creates thicker skin where darker hair will appear later and thinner skin where the lighter color will appear later. Through further study, there were able to find a gene called DKK4. This gene was found in the thickened skin but not the thinner skinned areas. They found that there could be mutations of this gene which coded very differently for the color pattern of the cat. Brash concludes by explaining although they have found this DKK4 gene and know it interacts with a specific group of proteins known as WNTs, it is still unclear how the DKK4 gene can "remember" the target coat color it produces. 

Sunday, August 1, 2021

Cats: The New Practical Models for Human Genetics?

 

    According to Leslie Lyons, of the Department of Veterinary Medicine and Surgery at the University of Missouri, domestic cats may have the potential to become practical models for human genetics. Domestic cat genes are relatively the same size as human genes, as well as a genome that is both very organized and conserved. Alike to humans, cats are prone to genetic diseases that are related to a dysfunction in their genetic dark matter. Genetic dark matter refers to the approximate 95% of our DNA that is nearly identical throughout the entire animal kingdom. This dark matter has long been seen as extra genetic information with no real purpose, however, recent studies in mice suggest that the DNA dark matter holds essential factors to our development. Due to domestic cat genes having parallel spacing and similar organization in comparison to humans, there may be a greater potential to learn more about Alzheimer’s and blood cancer in mankind. Therapies for genetic diseases such as polycystic kidney disease, which affects both cats and humans, can also be discovered and used to treat humans. Domestic cats also are are more affordable and typically more docile in comparisons for other "lab setting" animals used for genetic discoveries such as monkeys. Overall, cats may be able to get scientists closer to understanding new crucial information pertaining to human disease in comparison to mice and monkeys that are being examined instead. Cats can play a role in developing precision medicine, where instead of finding a cure or treating the symptoms of a genetic disease, scientists can modify and fix the actual gene and what it does.

Helpful Links:


By Katherine Morone

Thursday, July 29, 2021

Cats and Their Importance to Studying Human Genetics and Medical Science


    Dr. Leslie Lyons, a professor in the Department of Veterinary Medicine and Surgery at the University of Missouri, says that there are many reasons that cats and their diseases can be valuable models for the study of human diseases. Dr. Lyons believes that cats are extremely underappreciated in the scientific community, but after extensive research determined that the cat genome is organized in a manner that is similar to that of the human genome. Dr. Lyons recognizes that pets can get similar diseases to humans, which can help gain a better understanding if they know how their genomes are constructed. Cats can also be an asset in gaining a better comprehension of genetic “dark matter”, making up roughly 95% of our DNA, yet 10% of noncoding genes within the dark matter of the genome are conserved across mammals. Studies have shown that cats can have genetic diseases as a result of dysfunctional genetic dark matter, which can make them a great model organism for these types of studies. Cats can also provide more information about the human genome because of the fact that we have the technology to clone cats and make transgenic cats. The first cloning of cats saw results that disagreed with Mendel’s laws and other genetic principles, and researchers were just beginning to understand that something was happening within these genes. On top of this, cats can also provide unique information relating to precision medicine for genetic diseases. As opposed to treating these symptoms, researchers are able to fix the actual gene that is dysfunctional and change what it does. If these diseases are able to be treated via precision medicine in cats, this information can be transferred over to humans in the future. Although cats have been around for thousands of years, the bias stands that it is a dog world. These recent studies, however, revealed that cats are closer to humans than dogs are, in genetic terms, which could possibly make cats man's new best friend.

Link to Study: https://www.sciencedaily.com/releases/2021/07/210728111322.htm

Link to Article: https://www.nytimes.com/2021/07/28/science/cats-genome-health.html


Thursday, April 15, 2021

Cats and a Plant Based Diet

 


In an act to live a healthier life and to reduce our ecological footprint, humans have developed a vegetarian diet. Vegetarian diets cut out all products associated with meat, taking out a main environmental issue, which is slaughtering of animals. Aside from humans having a vegetarian lifestyle, some wondered if pets could also live this way. The issue with giving cats a diet that lacks meat is that they are known to be carnivores. Humans can have a vegetarian diet since we are omnivores, meaning we eat both meat and plants. But there is a main reason why cats are carnivores. Daniella Dos Santos, the president of the British Veterinary Association, told BBC Future: “cats are obligate carnivores. They require certain amounts of amino acids to be healthy, and the lack of these can lead to health problems.” 

The Amino acids that plants lack is the main reason why cats can’t be fed a vegetarian diet. Scientists still say that cats could potentially live a vegetarian lifestyle, but it has to be done gradually. You have to let your cat's body become adjusted to the change in diet, you can’t just force the change immediately. While I personally disagree with making cats have a vegetarian lifestyle, some pet owners can make this decision ethically if they carry out the process slowly.

Is a Vegan Diet Safe for Cats? What Every Pet Lover Needs to Know (livekindly.co)


Why Can't My Cat Be Vegan? | ASPCA


Tuesday, April 13, 2021

The Genetics of Calico Cats



Calico cats are a beautiful example of sex-linked genetic traits at work. Calico cats are almost always females. Cats have a sex chromosome similar to humans where females have an XX and male have an XY. The pigmentation on calico fur is due to the process of Lyonization. This means that the traits on one X chromosome is activated and one is inactive. This type of allele can only occur when there are two X chromosomes which is why it is unlikely to find a male calico. Although, not impossible. 

These color markings on cats could aid in the survival of the cat in the wild. The image above the cat's color markings help the cat camouflage with the tree in order to protect itself from predators or make themselves hard to spot when stalking prey.



https://www.qps.com/2020/12/16/the-genetics-of-calico-cats/

 

https://letstalkscience.ca/educational-resources/stem-in-context/science-behind-calico-cats-colours


Sunday, November 15, 2020

Genetics of Polydactyl Cats

 

    Does your cat have extra toes? If so, they are polydactyl which is the presence of more toes than considered normal.  This trait has been found in many species, the most noticed is the domestic house cat.  There are two ways polydactylism is displayed, postaxial or preaxial. Postaxial being the extra toes on the lateral side of the extremity of preaxial on the medial side.   In the experiment linked below 70 Maine Coon cats from three months to ten years old were observed.   This study was looking for skeletal differences and if it affected their mobility.  Forty-eight of the seventy cats displayed affected mobility, but there was no way to determine it was from the presence of extra toes.   It was determined that polydactylism affects the carpus and tarsus, but had no apparent effect on the quality of life.   Moreover, polydactylism is not harmful to the animal it is present in.  


Links:

https://journals.sagepub.com/doi/full/10.1177/1098612X16628920?casa_token=iSro9myz2dwAAAAA%3AlZv2YQICgff_vqUyDJkcgjk-xYrEbeyK-2UQmzFYzmM1mQnflOrvn1-7RHL464OSuIE0qO_VLKvSXQ 

https://www.thesprucepets.com/polydactyl-cats-4175908 

Wednesday, April 10, 2019

Did Humans Domesticate Cats?

Dated back to ancient times, cat’s DNA showed that they domesticated themselves stated in an article on National Geographic website. Although cats now prefer to lay on the couch instead of outside their DNA shows that it hasn’t changed in thousands of years. Cats, even as wildcats, has been by a human’s side way before they became our house pets. A cat’s genes have only changed slightly in the past 9,000 years. This change appeared to be the dots and stripes on their coat of hair.

In this article, it states that researchers looked at DNA of over two hundred cats within the past 9,000 years and it showed that all the cats came from these two pedigrees; from Asia into Europe and Africa into Egypt. Both pedigrees showed that cats were not forced into being house pets, but just settled into it. Cats naturally patrolled around human's yards and killed mice and rats. They also were just attracted to humans, especially in the African lineage. 



Even though cats surprisingly attached to humans, the researchers still looked into the DNA of cats and it revealed that the DNA has not changed but the marking of its coat. When the coat of the cat was stripped, it showed that they were domesticated. This was not a definite identification of domesticated tabby cats until the 18th- 19th century.

The researchers suggested that the more we look into cats, the more we will understand the domestication process of animals. Being that cats naturally domesticated themselves, I do think further research into this animal could open up new doors or an explanation of how animals became domesticated.

Monday, March 26, 2018

Why Geneticists Hate Cats


Ok, they really don’t hate cats per say (or maybe they do, depends who you ask). In an article done by the New York Times explains how there is a minuscule amount of genetic research done on cat genome as compared to dog genome. Elinor Karlsson, a geneticist in specializing in dog genome at the Broad Institute and at UMass (who owns no dogs), feels that dogs are taken more seriously than cats, which is probably the cause of social biases. Many of the cancers found in cats are actually closer linked to human cancers rather than those of a dog, but there “has been almost no research into them”. The cancer that are found in dogs often vary by breed, and since there are so many breeds of dog (400 as compared to 40 cat breeds), it’s easier to study them since there is so much genetic diversity among the species.

According to Dr. Kate Megquire, a pre-DVM at the Broad Institute, insists that cats need more attention genetically. Cats are susceptible to lymphomas, and oral cancers that are biologically similar to human cancers, however she also states that, “these might be related to environmental toxins they pick up while grooming themselves”. She also stated that the feline genome is more detailed and more intricate than the current studies on the canine genome.

Elaine Ostrander at the National Institute of Health explains how there are eight genes that control body size in dogs, with the first gene causing small stature. Her lab also found a common gene mutation in German Shepherds that causes kidney disease before it was linked to cause cancer in humans. Elaine claims that domestication with dogs, “happened in an amazingly short period of time and we don’t understand all the genetics associated with it. It remains one of the most interesting and challenging questions in biology”.

Leslie Lyons at the University of Missouri also agrees with Elinor Karlsson. She says that the dog genome is widely studied because the certain cancers that they may obtain can be traced back to a common ancestor since there is so much species diversification however, there is a very low number of cat breeds. This is stems from a sociological conflict with the cat-lovers. Her reasoning is that cat people are not as interested in breeding their feline friends. There could be a cat that is the size of a Great Dane, but there isn’t because nobody has bred one to be quite as large yet. There is also a lack of funding for research for cats as well.

Dogs were also more widely eaten by ancient humans which means their remains were more easily obtained by researchers. The first evidence of a domesticated cat was over 5,300 years ago in ancient China, while the first domesticated dog is approximately 15,000 years old. Dog were bread in order to work (protection, hunting, farming), while many medieval humans did not see the use in cats, since they felt that they were harder to train.

This article was very informative. I own both a dog and a cat, but I have never thought about the genome for each animal. I also did not link dog and cat cancers to human cancers and that there is such a variation between the number of dog species and the number of cat species.  It's interesting to see how all these cancers can be traced back to a common ancestor and how certain cancer causing gene mutation in dogs can be linked to cancer causing mutations in humans.

(Related Article)

Wednesday, April 13, 2016

You Look Meow-velous in that Tuxedo

http://www.popsci.com/why-some-cats-look-like-they-are-wearing-tuxedos
http://www.nature.com/ncomms/2016/160106/ncomms10288/full/ncomms10288.html


To own a cat is to love one. These mysterious, beautiful, and arguably domesticated mammals have graced humans with their presence since as far back as 7500 BC. Although now, like dogs, there are many different breeds of cats, one ever-popular and recognizable appearance is the “tuxedo” cat. Cats with black/grey fur marked with white patches in this way are known as piebald. Piebaldism, caused by a mutation in the KIT gene, is also common in dogs, cows, horses and deer. However, it rarely occurs in humans.

Researchers at Oxford have been working on figuring out how these animals get their distinctive pattern. And it turns out that the mechanism for these patterns formations is far more random than originally believed.

Animals acquire piebaldism patterns when they are still developing embryos. Piebaldism arises when the precursors of pigment-producing cells spread incorrectly through the embryo. In normal development, pigment cells start near the back of the embryo and spread through its developing skin to the belly, the furthest point from where they started. As the cells spread they also multiply, creating more cells, some of which are left behind to ensure all the skin is pigmented. However, with piebaldism, the dark-colored pigment cells don’t make it as far as the belly in time to pigment the hair and skin. This results in distinctive white patches of fur and skin, usually around the belly of the animal.

Unlike what was previously believed, this study uncovered that cells in piebald animals migrate faster than in “normal” animals, but they do not divide as often. This leaves not enough cells to pigment all the areas of the developing embryo, hence the white bellies and faces. Using a mathematical model, these scientists were also able to demonstrate that pigment cells migrate randomly. 

This mathematical model created for this experiment has potential to be used to investigate other embryonic cell division, which can lead to many cancers and other debilitating diseases in humans such as Hirschsprung disease, Waardenburg syndrome and congenital central hypoventilation syndrome (CCHS).

Although I am not a math wizard (unlike my sister), there is no arguing that utilizing a mathematical model can lead to a deeper understanding that would be impossible with just experiments alone. In this specific casr too, it also meant that the researchers did not need as many of the piebaldic animals as they would have had to used if just using an experiment model alone. Using a mathematical model therefore can cut down a lot on time and funds needed. However, my favorite part of this research article was definitely learning about cats! If you can’t tell, I’m a cat lady! In fact, the picture used for this post is my furbaby Mimi, who herself is a tuxedo kitty.   

Thursday, April 30, 2015

Cats are on the Map




Cats have finally made their way into the spot light of gene sequencing. Thanks to a team of geneticists lead by Leslie Lyons of the University of Missouri the complete genome of 56 domestic cats of have been sequenced. The team’s results were unveiled at the Plant and Animal Genome Conference in San Diego, California in January of 2015 although their project is still ongoing.

The 99 Lives Cat Genome Sequencing Initiative began in 2007 with Cinnamon, a four year old Abyssinian cat whose linage is well known and can be traced back several generations. It is now known that there are 20,285 putative genes on 19 chromosomes in the cat genome. It costs around $7,500 to sequence one cat. Several different species have been sequenced so far and the team is still working on reaching their goal of 99 cat genomes. 
FCA-Ideo
The cat karyotype 

cats, cats, cats. <3