Rat Species Has No Y Chromosome!

Amami Spiny Rat

A team of researchers at Hokkaido University in Japan has figured out how a species of rat is able to survive and reproduce despite not having a Y chromosome. The rat species they studied was the Amami spiny rat (Tokudaia osimensis), a rodent native to the island of Amami Ōshima in southern Japan. The species, also called the Ryukyu spiny rat, is unique in that males do not have a Y chromosome and females only have one X chromosome as well. Previous attempts to study the rat have not been able to reveal how males are able to develop within the population with no Y chromosome. Typically in mammals, a gene on the Y chromosome called SRY tells the organism's body to express male genes like the SOX9 gene for testes. Not having the Y chromosome scientists were stumped at how males could develop. Lead researcher, Asato Kuroiwa, and her colleagues at Hokkaido have now discovered the answer! The secret was looking at the autosomes, non-sex chromosomes, in the rat. On chromosome 3 they found that one copy had a duplicated region next to the SOX9 gene. The duplication increases the activity of the SOX9 gene and it is able to code for testes. This duplicated region effectively replaces the SRY gene on the Y chromosome and explains how males of this species are formed. If a rat has the duplication region it acts as a proto-Y and the rat will be a male, and if the duplication region is absent, it acts as a proto-X and the rat will be a female. Further work to explore this is limited as the rat is an endangered species but the research so far has shown an amazing trait inherited by this rat population. The researchers predict the trait appeared about 2 million years ago when the Amami spiny rats diverged from their ancestors with a Y chromosome. Kuroiwa believes that a mixed population existed initially on the island but then a natural disaster like flooding or rising seas left mostly rats without the Y chromosome and over time the rats reproduced and evolved into a new species with this trait. 

Personally, this was my favorite article to read so far about genetics. I find it incredible that a species can exist without a Y chromosome and that another chromosome was able to replace its function to make males. This is a really interesting example of population evolution, genetic drift, and speciation. I hope that these rats can be studied more to learn about this unique and interesting trait. 

How the Brown Rat Conquered New York City

The brown rat has managed to populate New York city by the millions, with billions more in other cities across the world. They contaminate crops and food supplied and destroy wires, walls, and cars, while spreading bacteria and disease. However, scientists are not entirely sure as to how Rattus norvegicus became so rampant. Dr. Munshi-South and colleagues finished a study of brown rats that began to answer the question of what is a New York city rat and where did it come from? They found that these rats began spreading slowly for thousands of years, but in the past three centuries they spread much more rapidly. Dr. Munshi-South contacted researchers from around the world and obtained DNA from hundreds of brown rats, from Japan, New Zealand, Brazil, and the Galapagos Islands to name a few,  to compare to that of the rats of NYC. The study revealed that brown rats originated in northern China or Mongolia and fed on wild plants and small animals, until farming in China began, during which rats found a reliable food supply and moved from open plains to farms and villages. The rats then began to expand to other parts of Asia, and eventually west to Europe. It is these rats that are the ancestors of the inhabitants of New York today. As European countries colonized the Western world, they took the rats with them.

Dr. Munshi-South thought that he would find that New York's rats have a mix of genes from ancestors from all over the world, but he found little evidence of genetic mixing in New York or any other city. It seemed that there was not many migrants that arrived and reproduced after a city was already populated with rats. This could be because brown rats are territorial and simply mean, as noted by missing eyes and scars observed by Dr. Mushi-South in many rats. The theory is that the first rats to arrive in a city reproduce rather quickly, so when new rats come along, they are no match for the residents that have already inhabited the city. This is a good thing because it is unlikely that new diseases on new rats can come into a city that is already populated with rats.
Based on the results of the study, I think that we should not take action to eliminate brown rats. Although they do spread bacteria and destroy wires and walls, they are keeping out lots of potential disease because of their territorial nature.

Who Gets Hooked On Drugs?

A rat study done at the University of Michigan found genetic markers that influence addiction. 

People may ask why some people get addicted to cocaine after one try, while others will try it and be able to leave it alone. You may ask why some people are able to stay clean after rehab while others relapse. These questions may have a lot to do with the genetic factors that vary from person to person. Of course, we know that animal factors cannot explain all of the factors that lead to differences in addictions in human bodies, but the findings revealed information about the roles played by both inherited traits and addiction related changes in the brain.

The researches looked in rats' brains for the genetic instructions needed to make a key "pleasure receptor" called D2. It allows brain cells to receive signals sent by the brain chemical dopamine, or cocaine. They found that more addiction-prone rats had lower levels of D2 instructions to begin with when compared to the other rats, in an area of the brain known to play a major role in addiction.

The addiction-prone rats also were more likely to carry a specific mark on their DNA called an epigenetic tag. This tag called H3K9me3 kept their brain cells from reading the gene for D2 receptors, but after they became hooked on cocaine, the addiction-prone rats had the same levels of D2 as the less addiction-prone ones. When the cocaine was taken away for a while these rats were more likely to relapse to addictive behavior if they had started out with the epigenetic tag that kept their cells from reading the D2 gene.

I have always asked the question why people get addicted to drugs and others do not, but I have never thought it was a genetic factor in the brain. I always thought it was how you were raised or what influences from your environment affected you. I never thought to assume it was a genetic issue.