MIT Biologists Found a New Layer of Gene Regulation in RNA Splicing

A recent study, published in the MIT News, discusses how scientists have uncovered a new way RNA splicing is regulated, making gene expression more complex than before. RNA splicing is an important process where non-coding sections (introns) are removed from messenger RNA, allowing genes to create proteins. Scientists previously believed that splicesome, a RNA-protein complex, determined the splicing sites, but this study found that a family of proteins called Luc7 also play a major role. These proteins help decide which introns get spliced out, affecting almost half of all human genes. The researchers also found this process in plants, indicating it evolved early in life's history.

             This discovery could offer insights into diseases like acute myeloid leukmeia (AML), where faulty splicing is linked to cancer. It could also be helpful for targeted treatments like small-molecule drugs that stabilize RNA splicing at specific sites. Undertsanding how genes are expressed at such fine level is important in improving treatments in genetic disorders and cancer research.

Changes in RNA splicing: A new mechanism for genetic risk in schizophrenia

New research has identified sections of DNA associated with changed gene expression that causes schizophrenia. the loci effects the risks of schizophrenia by affecting alternative splicing. This is when the DNA is coded into different proteins. This finding will allow scientist to make more precise classification of culprit genes for schizophrenia and other brain disorders. throughout the research 4 disease susceptibility genes for schizophrenia that are effected through alternative splicing. 

schizophrenia, Alternative splicing