Showing posts with label #memory. Show all posts
Showing posts with label #memory. Show all posts

Sunday, December 8, 2024

Can Kidney Cells Make Memories?

 

Not quite. Kidney’s can make memories on a molecular level but not the type of memories we commonly think of. Kidney cells, like neurons, can store information and recognize patterns. The researcher, Nikolay Kukushkin, says that this does not contradict current knowledge on memories, it simply adds to current knowledge because they do not act like neuron memories. Other cells, like neurons, need to keep track of stuff that is going on which they do using a protein central to memory process called CREB. For a little background in memory in neurons, a chemical signal passed through them which then begins CREB production. CREB activated more genes which change the cell and start the molecular memory machine.

Through their experiment of inserting embryonic kidney cells with a glowing gene found in fireflies, they activated memory instructions in the kidney cell. The kidney cell responded to artificial chemical pulses which are like the signals which trigger memory in neurons. Different lengths of pulses triggered various levels of responses, or lighter. It is believed the newfound idea that cells can be given more complicated memory tasks, that this has a potential to introduce new potential drugs to treat disease, specifically memory loss related.

This has enormous potential, and I would love to see where it goes. It is currently just a thought and a small step in proving potential of this finding. I do not see why other cells could not mimic the process of neurons because at a simple level neurons are just specialized cells, so it makes sense that these kidney cells could perform this. It would be interesting to see this application in medicine or aiding those with memory loss.

Links

https://www.sciencenews.org/article/brain-kidney-cells-memory

https://www.hopkinsmedicine.org/health/wellness-and-prevention/inside-the-science-of-memory


Thursday, November 23, 2023

Lung cancer cells' 'memories' suggest new strategy for improving treatment



A common type of cell lung cancer that is mutated by the KRAS gene is called lung adenocarcinoma and researchers at Memorial Sloan Kettering Cancer Center have found new strategies for improving the treatment for it. Tuomas Tammela who is a cancer scientist who led the study found alveolar type 1 (AT1) cells which have a "memory" of their beginning as healthy cells. Also known as "AT1-like" cells which are cancer cells that remain while the KRAS inhibitor treatment is going on. The cell's presence is a negative thing since it leads to treatment resistance and can aid in the cancer coming back. The second article also supports the findings from the Science Daily article. 

The results from this study hope to help scientists come up with new improved strategies for lung cancer treatments and find a solution against the resistance of KRAS inhibitors. I believe that if they do more research and spend more time understanding the movements and functions of the AT1 cells they will find more meaningful discoveries which would help with the treatments. The researchers also plan to identify which surface proteins are different from AT1 cells and then create a therapeutic treatment that will bind both of them and kill them. 

Links 

- Lung cancer cells' 'memories' suggest new strategy for improving treatment | ScienceDaily

- Lung cancer cells' 'memories' suggest new strategy for improving treatment (medicalxpress.com)