Tuesday, December 13, 2016

MicroRNA: The Cure to Schizophrenia Voices?

Schizophrenia often occurs during late adolescence or early adulthood and is characterized by cognitive problems such as delusions and hallucinations. About 1.1 % of Americans are affected by schizophrenia every year.  Despite schizophrenia being so common and having many treatments, there are still unanswered questions. One question in particular is the origin of auditory hallucinations

Researchers at St. Jude Children's Research Hospital have been using mouse models in order to replicate genetic predisposition for schizophrenia. The model that researchers were studying in particular is the 22q11 deletion syndrome, also known as DiGeorge syndrome. By modeling this syndrome, it allows the researchers to observe the development of psychiatric conditions, some of which that lead up to the development of schizophrenia.  


While running the mouse model, scientists have identified microRNAs that can be served as useful for creating new anti-psychotic drugs with reduced side effects. MircoRNAs are non-coding RNA molecules that generally involved in regulating and silencing gene expression. The specific microRNA that is of particular interest to researchers is miR-338-3p. This specific microRNA regulates the manufacture of protein D2 dopamine receptor (DRd2) in which have a major role in auditory hallucinations. According to Dr. Zakharenko, auditory hallucinations that are typical in schizophrenia is related to high levels of Drd2 in the auditory thalamus.

Through the mouse modeling, the researchers have discovered that individuals with 22q11 deletion syndrome are missing Dgcr8 genes in which is essential for the production of microRNAs. Because of the reduction of Dgcr8 genes based on this study, this leads to an increase in DrD2, thus causing auditory hallucinations demonstrated from schizophrenia. Further results have concluded that by replenishing microRNAs, the Drd2 levels decreased thus restoring normal functioning within the auditory thalamus, thus leading to a cure to auditory hallucinations. This is an important breakthrough for anti-psychotic drugs. By using a natural process and the concepts of microRNA, it can serve a new basis for how drugs for treating mental disorders are made. In particular, the benefits of microRNA is that it can lead to more effective interventions with limited side effects. With such an important discovery, this research can pave the way to tacking other mental disorders using the same concept. It will be very interesting to see how this research will progress and be beneficial in terms of psychiatric and medical research.

6 comments:

  1. Rose Weel is my name, I live in USA. I want to say to the whole world how my husband was cured of his Alzheimer’s disease. Brothers and Sisters, my husband is 78 years old. He is a retired US Army. He fought so many wars, and had encounter with so many dangerous diseases. Before he embarked on his last peace mission to Iraq they were administered injections that will enable them carry out their duties effectively. So they went to the battle field where he lost so many of his colleagues and also he was shot on his throat but bullets don’t have much effect on him. So after the battle he survived it and returned back to USA off course he was rewarded heavily by the government, and that lead to his retirement. But after his retirement, he began to behave funny like forgetting all he did in the past, and sometimes don’t recognize me his wife quickly. I took him to Military hospital, and the doctor said some king of liquid in his body is causing him so many reactions, and this is affecting his brain to cut the long story short, after much diagnoses using EEG, and also the test of PROTEIN 14-3-3 all pointing out to the fact that his brain has malfunction. So he was giving medicines but his condition was still becoming worse even while taking the medicines administered. So we went back to the military hospital, and he was finally diagnosed of Alzheimer’s disease and this the doctor said have no cure. So his conditions began to get worst by the day. I cried out for help, but the government only gave us financial support. I all the time surf the web looking for possible cure until I ran into a blog where a man named James Watt gave testimony on how his cousin was cured of CJD by an herbal doctor called Doctor Uwadia Amenifo. In his testimony he imputed the contact detail of the herbalist. So I quickly copied out the contact details of Uwadia, and I contacted him immediately and explained to him what my husband is going through. He encouraged me and promised me that surly he will cure my husband, so after all necessary arrangement was made; he prepared the herbal medicine, and shipped it to me in USA, so I followed his instructions, and gave the medicine to my husband. Behold just like a magic in my eyes my husband was responding positively to the medicine and in just less than 3 weeks I started giving him the medicine, he was very okay, and in less than 7 weeks my husband was totally curd, and as I speak to you now my husband is totally cured, and he is now very okay, and in good health. So please all here shall help me say a big thanks to Doctor Uwadia Amenifo for helping me cure my husband of his Alzheimer’s disease. Please if you need Doctor Uwadia’s contact details, here is it. Email (doctoruwadiaamenifo@gmail.com) and his number is (+2349052015874). God bless all.

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  2. I am happy because today i am a living testimony. i want all here to know how i was cured of my schizophrenia. i was diagnosed of schizophrenia some months back. And my health begins to deteriorate gradually. It got to the extent that the symptoms was now all over my body. i have spent thousands of $$ in search for a cure but my doctor keep telling me no cure. i almost gave up. But on a very faithful day as my daughter was browsing on the internet, she saw someone who testified of how a herbal doctor by the name Doctor Ehidiamen cured him of his disease with the use of herbs. So she tried to get in contact with this doctor, and after she explain to him, he assured her that he can cure me of my schizophrenia. He gave me the steps to follow, i followed it and he prepared the herbs and send it to me in USA. i took the mixture according to his prescription and behold it worked perfectly for me. Today i am happy to say i totally cured of my schizophrenia and my family is happy together again. Please i want you all suffering from schizophrenia, or other brain related problem to also get cured just as i was cured. for this reason i want you all to contact the herbal doctor Ehidiamen. His email is email is: doctorehidiamen@gmail.com and his phone number is +2348102802949. Just explain to him what you are passing through and get his counsel and treatment. Thanks to you all.

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  3. I want to say a big thanks to Doctor Andre Armstead of USA for helping me cure me of my Brain disease. Brothers and sisters, Nath Luth is my name and I live in Texas USA. Few years ago I had a car accident and my brain was affected I was rushed to the hospital the doctor did his check and said I don’t have any internal injury in my brain but just that I was emotionally fragmented and for that reason I lost memory of what happened. But sometimes I sleep at night and I see in dream how I got the accident. But when dawn if am asked how it happened, I can’t say it. It continued like that and I found myself very forgetful. Doctor gave me medicines like Diuretics, Anti-seizure drugs, Coma-inducing drugs, to some extents the drugs helped but later on it stop helping me and as a result of this, I was fully diagnosed of schizophrenia (Brain Disease). Doctor said my problem was same with a variety of brain disease like salience syndrome, Psychosis, susceptibility syndrome, Asperger's Syndrome, Lemierre syndrome, Stevens Johnson Syndrome, Steele-Richardson-Olszewski syndrome, vascular dementia, CJD, mad cow disease, PTSD, encephalitis, panic disorder, OCD, ADD and a lot more. So i and my family became very afraid because doctor said I would die with it. My Immediate younger brother is an ICT officer he is always on the internet. So he came home and said he read about a herbal doctor called Doctor Andre Armstead who have used his herbal medicine to cure so many people of various diseases. So he copied out the contact details of the Dr and he contacted him. He emailed him, and explained to him what I was passing through but Dr Andre promised him that he will cure me of my brain disease and I will be totally cured for life. So he made the arrangement with Dr Andre, and he prepared the herbs from Washington and shipped it to us in Texas. So I followed his instructions on how to take it and behold it worked for me just like a magic, and totally cured me of my long suffered brain disease, and today I am totally cured of my brain disease. Please if you are out there suffering from any kind of brain disease, or you know someone suffering from it, I urge you to contact Dr Andre immediately and get your cure. His contact details are (doctorandreaarmstead@gmail.com) and his phone number is +1 (617) 663-8926, Thanks.

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