Saturday, November 4, 2023

Scientists take next big step in understanding genetics of schizophrenia


Researchers, led by the UNC School of Medicine, have made impressive findings in unraveling the genetic underpinnings of schizophrenia. They initially identified around 5,000 genetic variants associated with schizophrenia through genome-wide association studies (GWAS). To see which of these variants has a direct causal impact on the development of the condition, the team employed a specialized technique known as Massively Parallel Reporter Assay (MPRA). By introducing these variants into human brain cells in a controlled environment, they identified 439 genetic variations that have biological effects, capable of altering gene expression linked to schizophrenia. This study has discovered new genetic variations that could be involved in schizophrenia's genetic basis, helping us understand its complexity better.

Schizophrenia is known for its complicated interplay of genetic and environmental factors, and significant progress has been made in identifying potentially causal variants, but the condition remains versatile. The research emphasizes the need for further investigation into the genetic structure that contributes to an individual's liability for schizophrenia. In the end, what we've learned might help create better treatments or help get close to that step. This is very important because there aren't many good treatments available for this serious mental disorder.

1 comment:

  1. Schizophrenia is an intriguing condition, I do not know all that much about it, but one of the voices in my head does. In all seriousness I hope that this research is continued for the sake of new developments in treatments for the condition. I don't know if schizophrenia can be fixed with gene editing, but if it could be identifying these genes may be the first step in finding a way to cure the condition.