Monday, November 19, 2018

A New Approach to Detecting Cancer Earlier From Blood Tests

        Dr. Daniel De Carvalho an immunologist at Princess Margaret Cancer Centre located in Toronto, Ontario, has had scientists working hard to use "liquid biopsy's", such as blood tests, for epigenetic alterations to detect cancer in its earliest stages, enabling early treatment.  Dr. Carvalho describes that they are able to detect cancer at its earliest stages allowing patients easier treatment and no suffering.  This is done by profiling epigenetic alterations instead of its mutations.  This allowed the scientists to discover thousands of modifications specific to each type of cancer there is.  The scientists then used machine learning to be able to identify DNA present in cancer.  It is then able to use the blood sample to determine what cancer type is prevalent.  
            The scientists used 300 patients tumor samples and tracked the origin of their cancers and compared them to "samples from healthy donors with the analysis of cel-free DNA circulating in the blood plasma.  In every sample, the "floating" plasma DNA matched the tumor DNA.  The team has since expanded the research and has now profiled and successfully matched more than 700 tour and blood samples from more cancer types."  (University Health Network)  Some cancer types include lung, pancreatic, colorectal, breast, leukemia, bladder, and kidney cancer.  
             To further the study and expand their horizons they want to use a large populations blood samples that have been collected for months before they could detect it with cancer.  This will advance their abilities in cancer screening.  The biggest issue has been finding a way to detect cancer early enough, so that it can be treated quickly without further symptoms occurring, and hopefully this is the answer to all of our problems.

1 comment:

  1. The is groundbreaking research for the field of cancer studies. If this does in fact end up being the answer to all the cancer problems, the world will be a different place.