New research has been done using a molecule against APOE in mice, and this study may reduce brain damage by half. APOE is a gene that encodes for protein called apolipoprotein E, which can dramatically increase the risk of Alzheimer's. The E4 variant of APOE is expressed in over half the people with the condition, and those with both copies of the gene have a 12-fold higher risk of developing the disease Alzheimer's.
Dr. Holtzman and a Ph.D. student revealed that molecule called antisense oligonucleotide interferes with the production of the APOE protein, which can lead to less brain damage. They injected this molecule into newborn mice predisposed to the disease and a control group of newborn mice that were give a placebo of saltwater. This research that the APOE proteins had halved in the mice given the antisense molecule. This information suggests that the molecule has successfully staved off neuro-degeneration related to this disease.
This article provided a lot of information and the possible reasoning behind Alzheimer's. By discovering the involvement of the APOE gene in this disease may lead to a possible prevention or cure. This gene needs more research and one day hopefully will lead to a breakthrough and be able to help those with this disease.