Nonessential Yeast Genes Establishes Platforms for Testing Inhibitors of Human Proteins

This article is about how Nonessential Yeast Genes Establishes Platforms for testing inhibitors of human Proteins. Cross species complementation can be used to generate humanized yeast, which is valuable resource with which to model and study human biology. Humanized yeast is something that you can use as an in vivo platform to screen for chemicals inhibition off human protein drugs targets. In the article they also report the systematic complementation of nonessential yeast genes implicated in chromosomes instability ( CIN) with their human homologs. They studied and identified that 20 human-yeast complementation pairs that are replaceable in 44 assays that test rescue of chemicals sensitivity. 

https://www.genetics.org/content/214/3/735

https://pubmed.ncbi.nlm.nih.gov/31937519/

How Do Poisonous Frogs Prevent From Being Poisoned?

Have you ever wondered about how poisonous reptiles prevent themselves from being poisoned? An article published by Science Daily informs readers of how frogs are not affected by their toxins. Poisonous frogs use their toxins and other chemical properties for survival when eaten by various predators. The toxins released from the frog can cause seizures, hypertension, and even death. Researchers have discovered out of 2500 amino acids which make up the receptor , only three amino acids were mutated. These amino acid changes prevent the toxins from affecting the frogs own body. Also, the Science News  has published an article about how researchers can test the different protein amino acids and can test the effects of the changes. Not only did the researchers find out genetically, due to amino acid mutation frogs are prone to their own toxins, but experimented with the human protein. Replacing one of the amino acids in the human protein made it resistant to epibatidine and acetylcholine, which affect the nervous system. Genetically frogs are mutated, preventing toxins from affecting their body. This article was very interesting because this is something that people don't really think about, but is very interesting. Its cool to see how frogs don't get poisoned by there own toxins, but the article was very repetitive.  



https://www.sciencedaily.com/releases/2017/09/170921141238.htm

https://www.sciencenews.org/article/way-poison-frogs-keep-poisoning-themselves-complicated