This article is about how Nonessential Yeast Genes Establishes Platforms for testing inhibitors of human Proteins. Cross species complementation can be used to generate humanized yeast, which is valuable resource with which to model and study human biology. Humanized yeast is something that you can use as an in vivo platform to screen for chemicals inhibition off human protein drugs targets. In the article they also report the systematic complementation of nonessential yeast genes implicated in chromosomes instability ( CIN) with their human homologs. They studied and identified that 20 human-yeast complementation pairs that are replaceable in 44 assays that test rescue of chemicals sensitivity.