Showing posts with label #NOVA1. Show all posts
Showing posts with label #NOVA1. Show all posts

Monday, April 21, 2025

NOVA1: The Gene That Found Its Voice

    How humans developed the ability to speak has been a mystery to scientists for a very long time, especially because it doesn't leave behind physical evidence like fossils. A new study found a gene called NOVA1 changed a significant amount in humans somewhere around 250,000 and 500,000 years ago. NOVA1 might have played a role in helping early humans speak in more advanced ways. In a study, scientists inserted the human version of NOVA1 gene into mice, which resulted in the mice making more complex sounds, especially during mating calls. Dr. Darnell discovered that the human version of NOVA1 influenced the production of over 200 proteins in mouse brains, many of which are linked to how animals produce sounds. This points to NOVA1 potentially affecting the brain's control over speech-related behaviors. Dr. Jarvis and Dr. Darnell explain that NOVA1 is most likely just one of many genes involved in language development. The evolution of the gene became common in humans after we split from Neanderthals and Denisovans. Their research, along with studies on the FOXP2 gene, gives us new clues about how language might have evolved. 

 


    I chose this article because language is such a fundamental part of what makes us human, yet I never really thought about how it might have developed through genetics and evolved over time. It's fascinating how much the NOVA1 gene may have contributed to our ability to produce more complex sounds. I thought the study done using mice was especially interesting and informative because it demonstrated the impact the human version of NOVA1 has on brain function and sound production. When I found out that the mating calls became more complex with the introduction of the gene, I was honestly speechless. The study was a creative and effective way to connect genetics to speech-related behaviors, and it not only helped scientists better understand how language evolved but also made the topic more engaging and meaningful for me as a student.  

Friday, February 21, 2025

NOVA1 - The Mystery of the Gene That Made Mice Squeak Strangely

The Gene That Made Mice Squeak Strangely explores the challenge of understanding the evolution of human language. Referencing this study, researchers discovered a specific gene, named NOVA1, developed significantly between 250,000 and 500,000 years ago. Scientists then took that human version of NOVA1 and put it into mice. What did they discover? The mice then made more complex sounds.

Imaging of a mouse's brain, where the cells producing NOVA1proteins are colored green.

I find the most intriguing part of this research to be that out of 20,000 protein-coding genes, almost all produced proteins that were identical in most mammals. There were only 23 of these that were identical in mammals except for human beings. That's 0.115%. NOVA1 gained attention for being one of those 23. While it certainly is important to note, it's not a single gene that allowed us to develop the language abilities we have now, but many mutations over millions of years.

What is also fascinating about the NOVA1 gene is mammalian life appears dependent on its presence. A mouse without it is not viable, but there was little to show it played any significant role in our evolution.