How Gene Editing Could Solve the Organ Shortage

 

Gene editing offers a revolutionary solution to the ongoing shortage of human organs for transplantation by creating genetically modified animals, whose organs could be more compatible with human recipients. This process involves altering the DNA of animals (mainly pigs) to reduce the risk of immune rejection when their organs are transplanted into humans. For instance, researchers are using CRISPR and other gene editing tools to disable certain genes in pigs that cause immune rejection and to insert human genes that help the body accept the organ as its own. These gene-edited animals could provide a continuous, renewable source of organs, potentially saving thousands of lives each year.

However, there are significant concerns. Ethical issues surrounding animal modification, the welfare of genetically altered animals, and the long-term safety of these organs in humans are major challenges. Additionally, there are risks of animal borne diseases where these might transfer from animals to humans demanding strict safety measures. Another issue is the potential for a few large biotech companies to dominate the market, possibly making these organs too expensive for many who need them. Despite these challenges, with careful research, regulation, and ethical oversight, gene edited animal organs could become a vital solution to the global organ transplant crisis.