Thursday, November 23, 2023

Inheritance of Parkinson's Disease

                   Two puzzle pieces joined together representing parkinson's and genetics

Parkinson's disease is a progressive disorder that affects the nervous system and the parts of the body controlled by the nerves. There are 28 chromosomal regions related to Parkinson’s and six contain genes with mutations conclusively. About 15% of people with the disease have a family history of the condition with a mutation link along the family lineage. SNCA, PARK2, PARK7, PINK1, AND LRRK2 are the genes that the inheritance patterns depend on. If LRRK2 and SNCA are involved, then the inheritance is autosomal dominant; if the other 3 genes are involved, it is autosomal recessive. Both parents passed on the altered gene but may not have even presented with any signs of having Parkinson's disease themselves.


1 comment:

  1. Parkinson's is so interesting, and it's also interesting to note that it can be associated with Alzheimer's as well. We still do not know if Alzheimer's is genetic, but maybe this association can be more closely studied. Looking at the genes in PD; SNCA, PARK2, PARK7, PINK1, AND LRRK2, we could find possible links to other disorders as well! This was an interesting blog post to read, wish we could have heard your opinions on PD genes/inheritance!