
For the first time, a team of researchers shows that RNA
molecules can recognize one another to form into the same droplet. This is due
to specific 3D shapes that the molecules assume. They worked with fungus cells
and colleagues, which showed the RNA molecules ended up in the same droplets,
if these 3D structures allow them to bind to one another through base
pairing. They then found out that RNA
molecules will end up in different droplets in their secondary 3D structure is
shielding any complementarity. This
finding is important because it reveals a selective mechanism for forming these
RNA protein condensates.
They still need more evidence; with using fungus researchers
believed there should be a liquid-to-liquid phase separation in order for the
two different biological processes to occur. But they need more evidence that
matters for the cell function. There has also been indication that with these liquid
condensates that it should condense to more of a solid state may be a factor in
disease such as Parkinson, Huntington’s, and Alzheimer’s.
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