Stroke is the second cause of death worldwide, but the molecular mechanisms underlying the condition are poorly understood. In this study conducted, an international team of researchers used DNA sequences from more than 520,000 people to home in on 32 loci in the human genome that are associated with risk for the condition. The study was conducted by members of an international collaboration called MEGASTROKE, which aims to identify the genetic factors underlying the condition. Researchers collated data from 29 large-scale studies that had collected DNA samples all over the world from people of diverse ethnic origins.
This team discovered multiple loci in the human genome that corresponded to stroke risk, only ten of which had been reported in prior studies. The researchers also found that several genes pegged by the analysis are already targets for antithrombotic drugs administered routinely to stroke patients. Study coauthor Rainer Malik of Ludwig-Maximilians University says in the article that "These genetic findings represent a first step towards developing personalized, evidence-based treatments for this very complex disease.
Article Link: https://www.the-scientist.com/?articles.view/articleNo/52050/title/New-Genetic-Stroke-Risk-Factors-Identified/