Tuesday, March 14, 2017

Breathtaking gene discovery in Dalmatian dogs

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A new genetic study conducted by the University of Helsinki has uncovered a gene associated with acute respiratory disease syndrome (ARDS) in dogs specifically dalmatians. Acute respiratory disease syndrome (ARDS) is a condition of sudden respiratory failure due to fluid accumulation, and severe inflammation in the lungs.To diagnose acute respiratory disease most veterinarians will use  the method of  blood gas analysis that measures the levels of oxygen and carbon dioxide in the blood to determine how well the lungs are functioning.  In humans there are many causes for lethal respiratory distress such as pneumonia. In dogs the cause is a genetic disorder resulting from a defect in anillin protein which binds to actin, this protein is important in cell division and growth. Lack of anillin can lead to malformed epithelial structures thus inhaled air, will become trapped in the alveolar walls. The mortality rate in dogs that have ARDS is 100 percent if left untreated.Despite advances ARDS still remains one of the most difficult disease to treat. This gene discovery provides new insights into the mechanism of lung injuries that can lead to recovery or complete eradicate it from certain breeds. 


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