These scientists used a new technique, called single-molecule localization microscopy, in order to look inside mammal cells to see their chromatin complexes in order to find locations of each DNA molecule in the cell. This is done by using blinking dyes that bind to DNA. The chromatin complexes are looked at since chromatin tightly packs together DNA and proteins. When the chromatin becomes restricted and compacted when there is low oxygen and nutrient levels, transcription is reduced. Along with transcription being reduced, the mobility of linker histone H1 is also reduced. By looking at the results of this technique, different ways in which to stop the DNA from compacting can be more easily found.
The two articles that deal with this study that I found were very interesting, seeing as though a heart attack or stroke victim can still deal with more things detrimental to their health even though they survived the event. Knowing that the DNA compacts when oxygen and nutrient deprived, scientists and researchers can now work to prevent it from happening. These events happen every day to people around the world and to know something now that we did not know years or even months before the study was completed is a huge step forward in the right direction in making the long-term damage as short as possible.