
Yale University, Vanderbilt University, and the University
of Western Ontario collaborators want to work on a way to determine individuals
who are at risk for acute kidney infections (AKI). through genetic testing.
"This may uncover novel pathways to target for therapeutic
interventions," said senior author Chirag R. Parikh, MD, PhD, FASN of
Yale. Previous analysis methods of genetic AKI have limited the amount of
knowledge we could have on AKI's. Dr. Parikh says, "But technological
progress in genotyping has opened the possibilities towards hypothesis-generating
genomic screens and novel opportunities to explore polygenetic perspectives,
now spanning a wide array of possible analyses falling under the term
Genome-Wide Association Study (GWAS)".
They have identified that for patient's at risk for AKI there are 6 clusters of 3 or more SNP's on 6 individual chromosomes.
They were about to discover this by using GWAS methods at a hospital setting. The subjects were 760 adults with AKI and 669 controls that had been treated in ICU for surgery or recovery.
They have identified that for patient's at risk for AKI there are 6 clusters of 3 or more SNP's on 6 individual chromosomes.
They were about to discover this by using GWAS methods at a hospital setting. The subjects were 760 adults with AKI and 669 controls that had been treated in ICU for surgery or recovery.
I think this is a important finding in the medical field because better treatments can be created by learning more genetic information about people. This findings can save people from getting AKD(acute kidney disease).
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