Wednesday, November 12, 2014

On the way to Controlling Genomes

Genome editing is the control of adding, deleting, activating, or suppressing specific genes on DNA sequences.  Researchers have recently developed a new technique for genome editing.  The technique involves a system known as CRISPR-Cas (or clustered regularly interspaced short palindromic repeats-Cas).  CRISPR is a system used by bacteria to defend against viruses and other invaders; it targets and cuts DNA in a sequence-dependent manner to turn off or on genes that could harm the bacteria.

CAS9 Genome Editing


            Researchers are now utilizing this system to better understand and develop new ways to manipulate genes.  In addition to understanding and manipulating genes, the CRISPR-Cas system allows for increased accuracy and precision when targeting DNA.  This research has the potential to change the world.  Crops could be specifically altered to reduce or even grant immunity to diseases.  This could eventually be developed to work on people: genetically tailored drugs for your specific genome or changing you genome to grant immunity/resistance to disease.  One scientist, George M. Church, even predicted the possibility of de-extinction, human enhancement (develop human bodies suited for space and other hostile environments). Of course as exciting as gaining control over the human genome is, it raises the questions is it safe, effective, and morally right?  We are going to have to answer these question soon.
                

            I have always found control over the human genome to be fascinating.  The potential it has to improve the world is astronomical, which is why I thoroughly enjoyed reading this article.  It showed we are constantly advancing our techniques and approaches to handling the control of genes on DNA sequences.  When we finally gain the control over genes, we will be able to help the world and expand in all fields.  













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