Showing posts with label females. Show all posts
Showing posts with label females. Show all posts

Tuesday, December 7, 2021

Improving Animal Welfare Through Gene-Editing

 

    Researchers at Kent State University have newly found a way to gene edit and create fully female and fully male litters of mice with 100% efficiency. This could be incredibly useful in dairy and egg production. Seeing as the females in both of these industries are the required sex and the males get disposed of. In chickens, the roosters are culled and in dairy, the bulls are sent to auction or slaughtered. If we could create a herd of 100% females there would be no need to slaughter any males. This is not only profitable for the farmers but improves the welfare of these animals. Researchers also brought up the idea behind the use of these litters for science. Generally, in research, only one sex will be studied they explain and the others are removed and disposed of. In this case, they can genetically create research litters of the sex they prefer, therefore not "wasting" any animal. Decreasing the slaughter rate of many animals that were not specifically bred for that reason. This is a huge step in the way of animal welfare and quality of life. A note to make is that there were also no harmful effects to the surviving gene-edited offspring. The researchers make clear although this is a big step in genetic research, any future use in agriculture would have to be studied extensively before use on any farm.

Monday, November 23, 2015

Genetically Predisposed to Risk of ACL Rupture In Females

Rupturing the anterior cruciate ligament(acl) is considered to be the most horrific and feared injury in sports. The ACL is a ligament that connect the femur to the tibia and prevents the tibia from sliding in front of the femur. There has been a study that shows how based off of the lack of the  COL5A1 gene, athletes can be predisposed to tearing their acl. The major structural constituents of ligaments are collagens, specifically types I and V. Of late, the gene that encodes for the α1 chain of type I collagen has been shown to be associated with an increased risk of cruciate ligament ruptures. The COL5A1 gene encodes for the α1 chain of type V collagen, and has been shown to be associated with Achilles tendon injuries, which lead to the suspicion that the COL5A1 gene could also be correlated with ACL ruptures. The study had a control group of physically active females with no history of ACL tears and another group of females who all have history of ACL tears. The results showed that the ACL group severely lacked the COL5A1 gene, leading to a correlation between ACL tears and a lack of the COL5A1  gene.

Sunday, March 16, 2014

Genetic Differences Found in Female Athletes with ACL Injuries


              Almost everyone knows of someone who has injured their anterior cruciate ligament (ACL), as it is a very common injury in sports. However, people may not know that females are two to eight times more likely to injure their ACL than males. But, why is this true? Is it because of an anatomical or hormonal factor, or is it based on genetics?

 In a study recently performed at the American Academy of Orthopedic Surgeons, a biopsy of ruptured ACL tissue was obtained from seven male and seven female athletes. There were thirty-two differentially expressed genes isolated from the tissue, fourteen of which were not linked to the X or Y chromosome. These fourteen genes were grouped according to skeletal muscular development, function and growth. In females, altered responses in signaling pathways that regulate cartilage and tissue growth were found. Researchers believe that these findings will help determine the role of genetics in ACL structure, and the tendency toward increased injury in female compared to male athletes.

I found this article to be interesting, especially because I work with injured athletes on a daily basis, working at an athletic training room. However, I think more research needs to be done on this topic involving athletes of various ages and cultural backgrounds for the research to be considered substantial. Studies should be performed on much larger quantities of athletes, as well, as opposed to only fourteen being used in this study.