Rare Mutation helps Kill Gene that is linked with Diabetes

Can this finding help us cure diabetes?

          Based on recent studies conducted, diabetes can be destroyed by attacking the gene responsible for its occurrence. This study has been conducted on over 150,000 people who are either obese or overweight and saw that this mutation has been helping them attack the gene responsible for diabetes. Scientist have saw this mutation being very effective in the pancreas where insulin is made. This mutation has been attacking this gene just as our immune system attacks symptoms or viruses that link with the flu or common cold.

Does this finding come as a shock to scientist who have been working on this study for year ?

           In addition, most of scientists who have been studying the cure for diabetes have came to realize that this same mutation helping humans from developing diabetes is having an opposite affect on animals. Therefore, when scientist tried to kill the same gene with the mutation in animals it caused diabetes in animals instead of fighting it.

To conclude, scientist have found the mutation attacking ZnT8 gene in the human pancreas. Researchers conducted another test on more than 28,000 people based on weight, age, and history of disease where the mutation was in affect. From the 28,000 patients they saw that the mutation in most of the people had already destroyed the ZnT8 gene, which caused diabetes in the human body.

*Scientist have also realized this gene, ZnT8, is responsible for more than 750 disease, which are removed for those people who don't have this gene anymore because of this intriguing mutation developed within the pancreas. I believe scientist need to continue to search for these clues as it will serve a purpose for them in the near future into curing diabetes. The gene they have found seems to be the first clue and that will be the ground breaking evidence that will solve many mysteries. Diabetes itself may seem harmless but it is slowly killing you because it is slowly taking over every aspect of your body and making you addicted to medications to make you vulnerable to the side affects.

Rare Mutation Kills Off Gene Responsible for Diabetes

It is said that almost 26 million children and adults in the US have diabetes Researchers have identified a rare mutation in a gene that could prevent type 2 diabetes. The research that was led by investigators from the Broad Institute of the Massachusetts Institute of Technology and Harvard, and the Massachusetts General Hospital was started by analyzing the genes of 150,00 individuals over five ancestry groups. All the participants involved in the research had severe risk factors for diabetes.

After analyzing the genotypes of the individuals, researchers discovered that mutations in the SLC30A8 gene that reduces the risk of type 2 diabetes by 65%. After this discovery, further research helped to discover a second mutation in the SLC30A8 gene that also helped reduce type 2 diabetes. The only difference between this mutation and the first is that this one reduced blood sugar levels in subjects without diabetes and had no negative outcomes. Researcher, once again did more research and found another ten mutations in the SLC30A8 gene that reduced the risk of type 2 diabetes. They found that SLC30A8 disrupts the normal function of ZnT8, which is a protein encoded by SLC30A8 that carries zinc into beta cells that produce insulin. However, the researchers have not yet said how a reduction in ZnT8 reduces the risk of type 2 diabetes.

This great discovery can actually lead to great things in the future. It could be possible to completely reduce type 2 diabetes with the help of these mutation.