Showing posts with label UK Biobank. Show all posts
Showing posts with label UK Biobank. Show all posts

Monday, November 24, 2025

Ancient Genes, Modern Mornings: The surprising Link in Our DNA, Blog#5

 

https://www.nytimes.com/2023/12/14/science/neanderthal-sleep-morning-people.html?smid=url-

https://pmc.ncbi.nlm.nih.gov/articles/PMC5630192/?utm_source=chatgpt.com

https://www.theguardian.com/science/2023/dec/14/neanderthal-dna-may-explain-why-some-of-us-are-morning-people?utm_source=chatgpt.com

Thursday, November 23, 2023

The Underappreciated Genetic Footprint That Can Resolve Participation Bias

     No one can achieve perfection. A main issue faced in research studies is predominantly impacted by sampling bias, resulting in skewed results. In Genetic studies, participants and data are collected from genetic databases. As useful as the genetic database is, one problem arises. Most primarily ascertainment bias, in other words, genetic data collected does not accurately encompass the intended study population. This curiosity was credited to Oxford's Leverhulme Centre for Demographic Science and Big Data Institute, which conducted a study to understand why certain individuals stand out in the database. Using the largest biomedical databases. The UK Biobank brought attention to a genetic footprint left on ascertained genotypes, that corresponds to the trait of probability of participation of participants. Sounds like an easy fix for participation bias. Although evidence in alleles that are common in genetic segments of participants suggests correlation to the percentage of participants participating in studies. However, it is still difficult to compare genetic information of participation with nonparticipants directly. In theory, taking note of the variety of participant behavior, and health traits could improve analyses of the study data. Research is ever evolving to fully understand the main question. What is a gene?

Links:

https://www.ox.ac.uk/news/2023-07-13-participating-genetic-studies-your-genes-oxford-study

https://www.nature.com/articles/s41588-023-01439-2


Friday, November 12, 2021

Does Risk Of Disease Decrease With Age?

Our genes influence the risk for different types of diseases from heart disease to cancer. Genomic technology can be used to predict future risk of these diseases. A recent study from Gil McVean of the University of Oxford and colleagues determined that the impact genes have on the risk of getting sick decreases with age. Genomic data from 500,000 people in the UK Biobank was analyzed to see how their genetics impacted their risk of developing 24 diseases. Researchers determined that the highest risk for many genetic diseases, including skin cancer and underactive thyroids, is early in life and then decreases with aging. The magnitude and form of decrease varies with disease. The exact reasons behind why the risk decreases with age is not clear, but McVean and the team concluded that there must be underlying processes that they are currently unaware of such as the interactions between genes and the environment or gene-gene interactions. Future studies will hopefully determine why aging decreases the risk of developing genetically related diseases to help determine if someone will develop a disease. If we can determine whether or not someone will develop one of these diseases, we can take measures to lower the risk. It will be interesting for them to conduct more studies on this inherited risk because age is just one factor that varies among us.