The highly complex process of wound healing requires the coordinated response of various cell types, as well as the proper delivery of nutrients and oxygen to repair the damaged tissue. While superficial wounds tend to heal within a matter of days, deeper and larger wounds tend to heal by leaving a scar. These scars can be painful, restrict mobility, or impair function.
A recent review calls attention to the need for improved techniques or developments to both treat and prevent scarring. Research could be improved with the use of population health approaches and experimental validation in animal models. In the past, a wide variety of animal models have been used to study scaring. It is possible to take these studies further with the performance of candidate gene validation. Overall, these strategies may uncover links between specific genetic loci and wound related phenotypes in humans. Future experimental work in animal models can then be used to validate these candidate genes and deepen insight into the biological mechanisms involved.
Source:
https://www.sciencedirect.com/science/article/pii/S1748681525006588#sec0030
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