COVID-19 Vaccines with a Bit of Viral Polymerase May Work Longer

Vaccines made using RNA polymerase, a viral protein that the coronaviruses use to make copies of itself, may be more reliable than spike protein vaccines. This is because the spike protein is able to change its shape through different mutations of SARS-CoV-2 strains. This makes it difficult for maintain antibody resistance in response to COVID-19 vaccines. Researchers were able to find T-cells that target the RNA polymerase that is in other coronaviruses as well as SAR-CoV-2. The isolation pf T-cell receptors and the overexpression of allogenic cells allows for T-cell reactivity profiling. In order to activate the immune system's T-cells is to add a fragment of second viral protein to vaccines, that is less prone to mutations than the spike protein.