Antibiotic Resistance Predicted via Pathogen Pre-Resistance Genotypes
A study was done at the University College London [UCL] and Great Ormond Street Hospital [GOSH] on M. tuberculosis genomic signatures. The goal was to create the first evaluation of pre-resistant polymorphisms, two or more phenotypes. This allows scientists to predict drug resistance in pathogens coupled with targeted expanded therapy. This process could pave the way for drug resistance prevention in the future in many pathogens including M. tuberculosis. The results of the study concluded that M. tuberculosis linage 2 has a higher risk of developing resistance than linage 4. Linkage 2 had a higher hazard of rifampicin resistance following isoniazid mon-resistance.