Cancer cells need to use the mTOR pathway to move throughout the body. When cancer is present the mTOR pathway is very active to because it is vital for the synthesis of new tumor cells. Because mTOR is essential for all cells in the body, inhibiting it can lead to some bad side effects., Knowing that when in tumor cell mTOR produces much more SAM than usual, researchers at Northwestern University have done studies on mice, injecting them with tumor cells and giving them SAM inhibitors and testing the speed at which the cancer spread. Their results were overwhelmingly positive and as of April 9th Biotech company Celuity announced an agreement with Pfizer to develop and commercialize the first mTOR inhibitors. I think that once the mTOR inhibitors have successful results in being adjuvant therapy, the safer route of SAM inhibitors will start to be used and better cancer treatments will follow.