This article is about thyroid cancer. Thyroid cancer is the most common malignancy of the endocrine system. This is the 12 common cancer in the Unites States and about 52,070 people were reported in the year of 2019 with illness. This article also talks about different types of thyroid cancer. For instance Non-medullary thyroid cancer (NMTC) comprises the vast majority of thyroid cancer that arises from thyroid cells of follicular. Papillary thyroid carcinoma (PTC) demonstrates high heritability and a low somatic mutation burden relative to other cancers. Therefore, the genetic risk predisposing to PTC is likely our to a combination of low penetrance variants. The study demonstrates two separate mechanisms, one in G protein signaling and the other in transcriptional control, dictating PTC risk at 3q26 using the biochemical and genetic techniques.