Schizophrenia is a long-term mental disorder that involves a breakdown between emotion, behavior, and thought. This disorder tends to run in families and is mostly inherited. Researchers began to gather patients’ exomes for 24,000 people with schizophrenia and about 97,000 people without schizophrenia. Ten genes believe in finding that promote schizophrenia. GRIN2A, SP4 overlap with GWAS markers suggests high-risk mutations that boost schizophrenia risk. GRIN2A and GRIA3 encode for brain receptors for the neurotransmitter glutamate also suggest high-risk mutations as well. Scientists also suggest that the glutamate pathway is also the factor of schizophrenia due to how PCP and ketamine receptors blocked can boost the high risk of schizophrenia symptoms. Since scientists believe there might be something involved with the glutamate pathway, many are experiencing how to develop drugs that can prevent the receptors from being block.
|Picture from Verywell Mind|