Science Daily recently published an article discussing the research which was originally published in Nature Communications. This research was conducted by scientists at the University of Bristol. Dr. Adam Perriman directed the study which led to the advancement of surgical glue. This new technology involved modifying the membrane of human mesenchymal stem cells (hMSCs) with the enzyme thrombin. When these altered cells were combined with fibrinogen, which is found in the blood, they were observed to fuse together. This fusion occurred through the mechanism of a hydrogel on the surface of the cells. The success of this experiment was the solution to a big problem within cell therapies. It is unfortunately common for cell transplantations to fail, however this new technology equipped cells to grow an artificial extracellular matrix which provided them increased protection.
This amazing technology would decrease the time a wound takes to heal considerably. The use of cell therapies for surgical procedures also has the possibility of reducing post surgical infections from a wound which is not sealed efficiently. Reducing the number of hospital acquired infections would allow doctors and resources to be utilized elsewhere. In addition to being used as a welding technology, this invention could open the door for many other new biotechnologies.