The team from Penn contributed to the bioinformatics analysis of essential genes in humans and showed their relevance to human diseases. The researchers compared the genes analyzed in the paper with a list of known human disease genes which made it possible to identify the mutant phenotypes in the mouse for 52 human disease genes. The IMPC later showed that human version of mouse essential genes are depleted for harmful mutations in humans. As a result, the researchers believe that the genes are good candidates for treating rare diseases found within humans.
Before reading this article, I knew that mice and humans shared very similar DNA sequences. However, I did not know that mutant mice genes are related to human disease genes. The researchers were able to compare the genes analyzed in the paper with a list of known human disease genes in order to identify the mutant phenotypes in the mouse for 52 human disease genes. This was an amazing article that provided a detailed explanation about the comparison of genes found in mutant mice related to many human disease genes.

Very interesting! I wonder if these genes when altered in humans will still have a lethal effect. Could it be possible that the proteins created by these genes do not have a harmful effect on us? It's very cool seeing parallels of what makes us human in other species so that we can study them in order to learn more about ourselves.
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