Wednesday, January 28, 2015

Father’s pass on more mutations with age leading to increased risk of disorders

Autism and schizophrenia are two different types of disorders that over the years have seemed to occur more frequently among individuals. Autism is a developmental disorder which is on a very wide spectrum usually characterized by repetitive behaviors or fixations, and difficulties in social environments. Schizophrenia on the other hand is a mental disorder that majorly affects the way a person acts, thinks, and behaves.

According to an article in the New York Times, experts believe to have found a reason for an increased diagnosis of Autism and Schizophrenia. From recent studies they conclude that males who have children later in their life rather than younger have an increased chance of having a child who has Autism or Schizophrenia. They believe this is due to random mutations that occur with advancing paternal age in males. Their study results showed that children who were born to twenty year old males only had about 25 possible mutations, whereas a child born to forty year old males had 65 mutations that could contribute to these two disorders. From this study they concluded that males over the age of forty have a two percent greater risk each year they wait to have children.

I believe this is something important to think about when having children because a lot of couples will wait later in life to have children after they have their career which is good, but sometimes waiting too long can have negative affects toward the child that we may not think about.

4 comments:

  1. Did the study mention any correlation between the age of the mothers and the gene mutations? What I mean to ask is- Is it just the age of the father that is causing these genes mutations, or do you think it could also be the age of the mother and the age of the father?

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  2. Yes, the full study found that the age of mothers did not have an effect towards these developmental and psychiatric problems. They found that the genetic risk originates in the sperm not the egg, however in chromosomal abnormalities like Down syndrome they found that older women had a higher risk in passing on these chromosomal abnormalities. I think the age of both parents is important to consider when having children later in life because I feel like they both contribute to different mutations that can be passed on to the children.

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  3. That's pretty rad! Thank you for really going into detail with your reply, I was genuinely curious! :D

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  4. This kind of makes sense when you think about it. The longer you have been alive, the more cell divisions you have gone through and the higher possibility for mutations to have occurred. It's definitely something to think about as far as your individual risk, but i hope that there is never a limitation put in place as to what age you have to stop having children.

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