Friday, April 18, 2014

Breaking Bad Mitichondria

In this article, researchers have identified a mechanism that explains why people with the Hepatitis c virus get liver disease and why the virus is able to persist i the body for so long. The pathogen attacks the liver cells energy centers, mitochondria, which does not allow for the cell to fight off infections or diseases. Hepatitis c causes liver cancer. After the mitochondria are done being attacked the proteins tell the mitochondria to eliminate the damaged area, but the process to repair ends up aiding the virus making things worse. Mitochondria convert food onto a form of energy which is used by the cells. The virus stimulates the production of protein that induces viral damaged mitochondria. Although mitochondria help with fighting off the infections and diseases it also helps with keeping the virus infected cell alive. The virus is able to use the mitochondria to keep reproducing new cells and amino acids to help fuel its continuous replication and virulence. Understanding mitochondria is what keeps the virus going when attaining the hepatitis c disease.


http://jcs.biologists.org/content/123/9/1389.abstract

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