Recent technological developments in genomics have revealed a large number of genetic influences on common complex diseases, such as diabetes, asthma, cancer or schizophrenia. However, discovering a genetic variant predisposing to a disease is only a first step. To apply this knowledge towards prevention or cure, including tailoring treatment to the patient's genetic profile -also known as personalized medicine we need to know how this genetic variant affects health. Until now, researchers have been focusing on the effects of disease-associated genomic variants on DNA-to-RNA transcription, instead of the challenging question of effects on RNA-to-protein translation, says Dr. Polychronakos. Thanks to this methodology, we can now better understand the effect of genetic variants on translation of RNA to protein a powerful way of developing biomarkers for personalized medicine and new therapies."
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http://thednaexchange.com/2010/08/27/genetics-and-teachers/
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