Now that the topic of DNA has come up, the Lawrence Berkeley National Laboratory can be mentioned where epigenomic profiling was carried out. The researchers here have figured out the genetic basis of a certain type of feature difference within the DNA coding: the face. Axel Visel was the leader for this research with a doctorate in genetics who discovered there are specific gene-leveled sculptors determining the development of the facial feature in humans which are called the transcriptional enhancers. These enhancers came to be found out from the experimentation with mice along with deletion experiments. There is no exact idea of what the purpose of these enhancers are yet but the expression of specific genes within the face development is started with these regulating sequences (transcriptional enhancers).
Previously, enhancers were looked at by scientists but in the major places of the body: heart, brain, and organ systems, where regulation took place over thousands and thousands of base pairs. Gene expression became more precise through these enhancers controlling their target gene's expression in the development processes giving different phenotypic facial features. Over 4000 were predicted to be ongoing in the precision of facial genes from observing mice. The importance that came out of this research of defining face morphology, basically the skull, was that it provides a foundation for birth defect analysis so it could be built upon on.
Link 1: http://www.genengnews.com/gen-news-highlights/one-face-many-gene-level-sculptors/81249023/
Link 2: http://www.cdc.gov/ncbddd/birthdefects/cleftlip.html
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