This article discusses the use of protein to keep order in the nucleus of the cell. Dr Patrick Heun used fruit flies to test this theory. One protein plays a major role which is NLP protein. It helps bind the chromosomes near the nucleus. If that protein is missing DNA damage in the cell increases and cell division is impaired. This protein also plays an important role in centromere positioning. Where the protein binds to the chromosome depends on DNA packaging. There is a process called gene knock down, which scientist use to eliminate the protein NLP. By doing so, the centromeres fall apart and distribute themselves through the nucleus. There is an article attached of the geen knockdown in mice by using lentiviral vectors expressing small interfering RNA.
other article: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC149921/