Even though they did not find this compound, I believe this is a huge achievement in itself. They were able to map the structure of KMO which is such a huge deal because it was not done before, and took a great deal of time. Also, I believe that even though UPF 648 was not an ideal compound, it is a step in the right direction. I think that it is a huge accomplishment knowing that one day they could possibly find a compound to suppress Huntington’s.
Monday, April 15, 2013
The Huntington's Inhibitor
There has been research done at the Manchester Institute of Biotechnology on how an enzyme in the brain can interact with a compound for Huntington’s Disease. It is said that it actually inhibits the its activity. This means that it can be used as a possible treatment method. They first identified the molecular structure of the enzyme KMO, which is found in the brain. The found that a compound called UPF 648 was able to bind incredibly well to the enzyme thus acting like an inhibitor. The only problem was that it was not a molecule that would make it past the blood brain barrier. They are now on a search for other compounds that can act as great inhibitors but also make it into the brain through the blood.

Even though they did not find this compound, I believe this is a huge achievement in itself. They were able to map the structure of KMO which is such a huge deal because it was not done before, and took a great deal of time. Also, I believe that even though UPF 648 was not an ideal compound, it is a step in the right direction. I think that it is a huge accomplishment knowing that one day they could possibly find a compound to suppress Huntington’s.
Even though they did not find this compound, I believe this is a huge achievement in itself. They were able to map the structure of KMO which is such a huge deal because it was not done before, and took a great deal of time. Also, I believe that even though UPF 648 was not an ideal compound, it is a step in the right direction. I think that it is a huge accomplishment knowing that one day they could possibly find a compound to suppress Huntington’s.
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