Jens Guldlach, the leading professor, is a physicist with must interest in bio-physics published these findings in Nature Biotechnology in March, and describes how his team and himself used attached a molecular motor to a protein that could read ionic sequences as it moved through a pore one nucleotide at a time, making it easy to read each base pair without scrambling or having tangled strands of DNA. The team has already been able to read 6 different DNA sequences that were around 42 to 53 nucleotides in length. Gundlach describes the protein aperture as being one billionth of a meter in length, which is just large enough to fit one strand of DNA through at a time. The process is carried out by enclosing a MspA pore in a lipid bilayer membrane. They then bathe the whole aperatus in potassium chloride. Next they apply a voltage to the membrane which creates an ion current that flows through the protein pore. Then, when the molecules pass through the aperture, they generate a small but detectable, change in current which can be read and the base that entered the pore can be determined.
Friday, April 13, 2012
NanoReader Can Deliver Fast and Cheap DNA Sequencing
A breakthrough discovery made by a Professor of the University of Washington. He found that a nano-scale sensor can read a single molecule of DNA extremely fast and even more importantly, cheaply. This discovery has made the "genome sequencing while you wait" idea come even closer into the picture, making the possibility and availability of getting your sequenced genome fast and cheaply even more realistic. This innovation can make predicting many diseases including cancers extremely available to almost anyone and could turn out to be a huge medical breakthrough.
Jens Guldlach, the leading professor, is a physicist with must interest in bio-physics published these findings in Nature Biotechnology in March, and describes how his team and himself used attached a molecular motor to a protein that could read ionic sequences as it moved through a pore one nucleotide at a time, making it easy to read each base pair without scrambling or having tangled strands of DNA. The team has already been able to read 6 different DNA sequences that were around 42 to 53 nucleotides in length. Gundlach describes the protein aperture as being one billionth of a meter in length, which is just large enough to fit one strand of DNA through at a time. The process is carried out by enclosing a MspA pore in a lipid bilayer membrane. They then bathe the whole aperatus in potassium chloride. Next they apply a voltage to the membrane which creates an ion current that flows through the protein pore. Then, when the molecules pass through the aperture, they generate a small but detectable, change in current which can be read and the base that entered the pore can be determined.
Jens Guldlach, the leading professor, is a physicist with must interest in bio-physics published these findings in Nature Biotechnology in March, and describes how his team and himself used attached a molecular motor to a protein that could read ionic sequences as it moved through a pore one nucleotide at a time, making it easy to read each base pair without scrambling or having tangled strands of DNA. The team has already been able to read 6 different DNA sequences that were around 42 to 53 nucleotides in length. Gundlach describes the protein aperture as being one billionth of a meter in length, which is just large enough to fit one strand of DNA through at a time. The process is carried out by enclosing a MspA pore in a lipid bilayer membrane. They then bathe the whole aperatus in potassium chloride. Next they apply a voltage to the membrane which creates an ion current that flows through the protein pore. Then, when the molecules pass through the aperture, they generate a small but detectable, change in current which can be read and the base that entered the pore can be determined.
Subscribe to:
Post Comments (Atom)
No comments:
Post a Comment