Showing posts with label epidermis. Show all posts
Showing posts with label epidermis. Show all posts

Saturday, April 14, 2018

Gene Therapy Creates Replacement Skin to Save a Dying Boy

Specialists in Europe utilized quality treatment to develop sheets of solid skin that spared the life of a kid with a hereditary sickness that had devastated a large portion of his skin.


This was not the principal utilization of the treatment, which adds quality treatment to a procedure created to develop skin unites for consume casualties. In any case, it was by a long shot the most body surface at any point canvassed in a patient with a hereditary issue: nine square feet.

The kid's illness, junctional epidermolysis bullosa, causes to a great degree delicate skin that rankles and tears, and is inclined to contaminations and skin tumor. He had been required to kick the bucket however has recuperated. Two years after the treatment, he keeps on having sound skin and have an ordinary existence. A video gave by the restorative group demonstrates the kid, Hassan, playing soccer with his dad. As indicated by news reports, the family is initially from Syria.

Epidermolysis bullosa takes different structures, contingent upon the hereditary transformation included. Around 25,000 individuals in the United States have the condition, and 500,000 around the world. The seriousness changes, however a few patients spend a lot of their lives canvassed in gauzes and in extreme agony.

Brett Kopelan, who has a kid with the ailment and is official executive of a help and support gathering, Debra, said that the profoundly specific dressings his girl needs cost more than $500,000 a year.

Click Link 1 and Link 2 to read the amazing articles and how this boy's life was saved!

Friday, November 24, 2017

Using Genetically Modified Grafts on Damaged Skin


Junctional epidermolysis bullosa (JEB) is a rare genetic condition that prevents the epidermis from attaching to the base underneath.  This condition results in fragile skin that is prone to tearing, and results in death after adolescence.  This occurs due to a deficiency of the protein laminin-33 and caused by a mutation in one of the three genes.  A gene therapy technique using an unaffected area of skin and using a retrovirus to implant the correct DNA sequence in the skin cells was done on a child in Germany with this condition.  The cells are then cultured to grow bigger patches of new skin, it is then attached to protein fibrin and grafted onto the body.  The longevity and health comes from the presence of living stem cells in the epidermis.  The new cells produced become apart of the epidermis from the stem cells that continue to replicate.
This technique seems very helpful for those who live with the rare disease JEB.  To be able to use skin that is not affected and using it to correct the DNA sequence in skin cells can maybe give some insight on helping burn victims. 

http://blogs.discovermagazine.com/d-brief/2017/11/08/skin-genetically-modified-grafts/#.Whjc2rQ-dPM
https://www.nature.com/articles/nature24487.epdf?referrer_access_token=jm8XfnchucFOrSLoRTxCDtRgN0jAjWel9jnR3ZoTv0OSWviL8WF5ZttJjAsMRX_zYMy9iodH9V74dB160PLsaZw-pV_GyFMdR4OTta00NXn0mRUc9GSr6Dg9L6uFp0z97CUKvDsrRlt3L25o53OVaCozS61Mr5nPW6fBCptCn9-xQ8vwkd_TvJgqUQSE28toGiZuKzVfP04dYGxLI3l2KKKEgqJtsRkAN-Y1HBdCmcOJQdgJsl09Zbjcl5WoNc0PgwnRE05alWlNIss2unbsoQ%3D%3D&tracking_referrer=blogs.discovermagazine.com