A study that target sequenced 88 neurodegeneration-related genes with the purpose of identifying somatic mutations that contribute to Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) also connected specific variants with widespread neurodegeneration. The predicted deleterious single nucleotide variants (SNVs) in ALS and FTD located at DYNC1H1 and LMNA affect multiple central nervous system pathways. Certain alleles of these genes are associated with motor neurodegeneration or severe pediatric diseases with life-precluding ALS. Together, these mutations predisposing to neurodegeneration suggest a broader array of related genes. With the expansion of targeted gene sequencing for numerous neurodegenerative diseases, more commonalities may be discovered.
Source:
https://www.nature.com/articles/s41588-026-02570-6
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