Blood Vessels in Muscles

Carmine Martino

BIOL-2110-001

Dr. Guy Barbato

April 23rd, 2026 

    Researchers identified a gene called RAB3GAP2 that acts as a “brake” on the formation of blood vessels in muscles. When the activity of this gene is reduced, more capillaries can form in muscle tissue. Capillaries are the smallest blood vessels in the body and are responsible for supplying muscles with oxygen and nutrients.

    The research was based on muscle and DNA samples from more than 600 individuals, which allowed researchers to study differences in the number of capillaries in muscle tissue. Through this, they were able to identify a genetic variant that is associated with how many capillaries a person has. The findings also showed that the activity of this gene is not fixed and can be influenced by external factors. High-intensity training was found to reduce the activity of RAB3GAP2, which may lead to increased formation of blood vessels in muscles. This suggests that physical activity can affect how genes influence the body. By identifying this gene and its role, the research helps explain why there are differences in how muscles adapt and develop in different individuals. It also shows that both genetics and training play a role in the formation of blood vessels in muscle tissue.

    At the end of the day, these findings highlight how genes can regulate important processes in the body and how their activity can change under different conditions.

Article:

 https://www.news-medical.net/news/20260218/Researchers-identify-a-genetic-brake-for-the-formation-of-blood-vessels-in-muscles.aspx

Extra Source:

https://www.sciencedirect.com/topics/medicine-and-dentistry/muscle-capillary