A group of MIT scientists at the Institute For Brain Research found a gene editing tool potentially better than CRISPR. The head of the research Feng Zang has talked about how they found this RNA system by identifying proteins with similar structure to CRIPR and alike systems. The researchers after finding IS110 protein capable of spilcing used AI technology to accurately research potential similar proteins in oher areas. While searching for this programable system they found Tandem Interspaced Guide RNA(TIGR) found in bacteria and viruses. This anciently related to human RNA system has the potential to accurately splice any DNA segement without PAMs (protospacer adjacent motifs) like while using CRISPR.
This new RNA system has given them so much further research to explore as this system has a dual guide system making this possible. They are currently researching these ancient viruses further to find a usable version of this TIGR system. With the possibility of this being easier to use then CRISPR with the automatic ending of its segmentation they think it will be able to grab any gene. It's old relation to human DNA has allowed TIGR to be capable of human genome editing. They are looking forward to this new research as TIGR might be even more capable of gene therapy in the future then CRISPR has been able to accomplish thus far.
https://news.mit.edu/2025/ancient-rna-guided-system-could-simplify-delivery-gene-editing-therapies-0227
https://www.science.org/doi/10.1126/science.adv9789
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