After difficult births some newborns can experience seizures, and breathing issues leaving doctors very little time to identify any other signs of neurological dysfunctions caused by a brain injury. However scientists have recently discovered a potential biomarker for neonatal encephalopathy which could help scientists make decisions about preventative measures, and different options for therapy. The noninvasive biomarkers are specific miRNAs found within blood samples. Without biomarkers Physicians struggle to determine if a newborn has brain damage and if therapy would be helpful. The lead scientist, Kobeissy, and his team acquired blood samples from infants that had experienced hypoxic stress. By using a microarray to measure the levels of miRNAs of newborns that did and did not develop neonatal encephalopathy within six hours of birth they were able to find elevated levels of miR34c-5p, miR491-5p, and miR346 in infants that developed neonatal encephalopathy. This means these miRNAs have the potential to serve as biomarkers for neonatal encephalopathy.
https://www.the-scientist.com/tiny-biomarkers-for-small-patients-with-brain-injuries-72015
https://www.nature.com/articles/s41598-024-57166-z#:~:text=These%20attributes%20highlight%20their%20suitability,implicated%20in%20conditions%20like%20NE.
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