AI can improve Alzheimer's treatment through the 'gut-brain axis'

(Machine learning crunches the numbers to more easily spot drug targets for diseases influenced by the gut microbiome) The combined analysis included: Proteomics and genetic information from human and preclinical Alzheimer's disease research reveals how various metabolites and receptors (protein structures) influence patient-derived brain cells, utilizing brain cells taken from Alzheimer's disease patients, the researchers looked at the metabolite-receptor combos that had the best chance of impacting the condition. Agmatine, a protective metabolite that is believed to protect brain cells from inflammation and related damage, is one of the molecules they concentrated on. According to the study, agmatine was more likely to interact with the CA3R receptor in Alzheimer's patients. Artificial intelligence is being used by researchers to investigate the connection between Alzheimer's disease and the gut microbiota. Prior research has demonstrated that as Alzheimer's progresses, individuals have alterations in their gut flora. The paper describes a computational approach to find out how metabolites, which are byproducts of bacteria, interact with cell receptors and cause Alzheimer's disease. The combined analysis included: Proteomics and genetic information from human and preclinical Alzheimer's disease research reveals how various metabolites and receptors (protein structures) influence patient-derived brain cells, utilizing brain cells taken from Alzheimer's disease patients, the researchers looked at the metabolite-receptor combos that had the best chance of impacting the condition. Agmatine, a protective metabolite that is believed to protect brain cells from inflammation and related damage, is one of the molecules they concentrated on. According to the study, agmatine was more likely to interact with the CA3R receptor in Alzheimer's patients.

Citations: Cleveland Clinic. "AI can improve Alzheimer's treatment through the 'gut-brain axis'." ScienceDaily. ScienceDaily, 22 April 2024. .