Friday, April 12, 2024

Genetic Links to HPV Persistence: Paving the Way for Personalized Cervical Cancer Prevention

Researchers at the University ofMaryland School of Medicine have conducted a study that identified certain genetic variants that increase women's susceptibility to human papillomavirus (HPV) infections. These genetic variants are found more frequently in women who have a higher risk of developing cervical cancer. This study is the first to identify specific genetic markers, such as rs116471799 located near the LDB2 gene and other variants around the TPTE2 gene, linked to prevalent and persistent high-risk HPV infections. Based on these findings, researchers developed polygenic risk scores to assess the probability of these infections in individuals, potentially helping to create personalized prevention strategies for cervical cancer.

In my opinion, despite declines in cervical cancer rates among younger women who benefit from HPV vaccinations, rates are increasing among middle-aged women, and these discoveries could lead to better treatment for women who do not have access to the vaccination.  

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