A recent study tracking proteins suggests that aging processes in individuals are not uniform, with organs aging at different rates among people of the same chronological age. Analyzing 11 major organs in over 5,600 participants, the study found that approximately 20% met criteria for accelerated aging in at least one organ, linking hyper-aged organs to a higher disease prevalence and increased risk of premature death. Testing proteins related to organ age could aid in developing treatments for age-related health issues and guide personalized treatment plans. The research explored the biological age of organs based on blood protein levels, revealing associations between accelerated organ aging and disease risk. While previous research identified cellular hallmarks of aging, including DNA mutations and epigenetic changes, this study emphasizes the role of protein shifts in organ aging. Researchers suggest that combining various aging hallmarks could lead to more robust organ age tests, though questions remain about whether identified proteins drive aging or are by-products, and whether the algorithm predicts disease risk or reflects protein changes caused by diseases. Though there is still a lot of questions that need answering, identifying the aging performance of organs could allow researchers to determine ways for extended lifespans.
This is informative. In my opinion, if 11 major organs in over 5,600 individuals are analyzed and the study found that approximately 20% met criteria for accelerated aging in at least one organ, linking hyper-aged organs to a higher disease prevalence and increased risk of premature death then this should be a major point of concern for us.
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