Clever dosage control mechanism of biallelic genes

In a remarkable study led by Asifa Akhtar's team at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg, researchers discovered a critical mechanism that ensures the appropriate expression of haploinsufficient genes. The study provides light on the relevance of having two copies of each chromosome and presents the epigenetic regulator MSL2 as an "anti-monoallelic" component that acts as a guardian of biallelic gene dosage.

Nature's built-in redundancy mechanism is the human body's presence of two alleles for each gene. This redundancy protects against the deleterious effects of mutations or decreases in messenger RNA production from a single allele. A subset of genes known as haploinsufficient genes, on the other hand, rely on the continuous expression of both intact alleles, making them vulnerable to disorders if only one allele is damaged.

In my opinion this is a very useful study that they have done here to help when both haploinsufficient genes are not compromised. This can help prevent many people from getting diseases that are caused by this. I believe this can help us discover even more genetic procedures to help cure even more diseases.

Links: https://www.sciencedaily.com/releases/2023/11/231129112532.htm

https://www.ivanhoe.com/news_flash/clever-dosage-control-mechanism-of-biallelic-genes-click-here/