Saturday, November 25, 2023

How the Three dimensional Genome is Being Mapped by Scientists

A team of researchers discuss in this report the computational methods used to determine the three dimensional shape of the genome. They discuss the parallel development of full-genome mapping techniques and advanced computational methods and how these two things come together to create a more complete view of genome structure in the 3D form and how the 3D form relates to the function of the genome.


Zhang, Y., Boninsegna, L., Yang, M. et al. Computational methods for analysing multiscale 3D genome organization. Nat Rev Genet (2023).

One of the more recent genome modeling platforms

Boninsegna, L., Yildirim, A., Polles, G. et al. Integrative genome modeling platform reveals essentiality of rare contact events in 3D genome organizations. Nat Methods 19, 938–949 (2022).

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