Friday, November 17, 2023

Eosinophilic Asthma how Interleukin 4 and 13 inhibitors are used to treat it

Eosinophilic asthma is a subtype of asthma that is often severe and characterized by the number of eosinophils found in the blood, lung tissue, and sputum in the respiratory tract. Asthma is defined as chronic lung disease the airways are inflamed with inflammatory cells and thickened walls and are obstructed with fluid and mucous. It causes spasms in bronchial tubs causing difficulty breathing. People with Eosinophilic asthma are known to suffer more from sinus infections and nasal polyps. There is a new type of medication that the FDA and researchers have been using to battle this type of asthma which is Dupixent (dupilumab) it is a dual inhibitor of the IL-4 and IL-13 signaling local and systemic type 2 inflammation in asthma where it binds to the IL-4 alpha receptor. Interleukin 4 and IL 13 are critical in allergic inflammation which is what eosinophilic asthma is. They both contribute to systemic and local (bronchial tube) inflammation. B-cell class switching and immunoglobulin E production. Geneticists have not been able to find a link between what causes eosinophilic asthma but there are other genetic links to regular asthma which associated with ADAM33, VDR, DPP10, PHF11, HLA-G, and GPR154. The genes are associated with elevated IgE, atopy, and bronchial hyperresponsiveness.,transient%20increase%20in%20blood%20eosinophils.,Phase%203%20studies%20of%20uncontrolled

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