Mutations in 11 genes associated with aggressive prostate cancer

A team of researchers has recently discovered that aggressive forms of prostate cancer are linked to mutations in 11 genes after studying and analyzing samples from 17,500 prostate cancer patients. Different genetic tests are helping to customize and create different treatment options to help target these mutations. Test findings are also leading to different genetic screenings, which are giving people the chance to take the needed measures to help reduce risk and be more preventative if they have these mutations present. In addition, the 11 genes that had mutations included BRCA2, which is well known for its connection to breast cancer. While this study is very informative and groundbreaking, the two limitations discussed were sample size and only testing people of European descent. Other studies can aim to get a larger sample size and a more diverse background of patients.

Each year, over 34,000 people are dying from prostate cancer. If we can find a genetic cause for this, we can better treat this form of cancer. Genetic testing can also be helpful in allowing patients to be more preventative, and maybe avoid getting this type of cancer before it is diagnosed if a mutation in any of those 11 genes is found.

https://medicalxpress.com/news/2023-09-mutations-genes-aggressive-prostate-cancer.html 

https://keck.usc.edu/largest-ever-genetic-study-of-prostate-cancer-in-men-of-african-descent-finds-new-risk-factors-for-the-disease/