A geneticist in germany has linked three genes to a rare condition referred to as "uncombable hair syndrome". Although very rare, with only about 100 cases reported, 71% of cases were attributed to a mutation in the PADI3 gene. This gene is responsible for the formation of the hair shaft, and this mutation causes the hair shaft to be formed with a groove in it. This causes the hair to stand up and stick out, no matter how much it is combed. A small percentage of cases were attributed to mutations with the TGM3 or TCHH gene, but a quarter of the cases are still unexplained.
The condition seems to improve with age, and has no side effects detrimental to the health of the individual.
Relevant article: https://www.sciencenews.org/article/uncombable-hair-syndrome-gene